Theory of solvation and its application to the supercritical fluid extraction/supercritical fluid chromatographic analysis of pharmaceuticals.
The roam objectives of this PhD project were to relate anal~ te solubility in
supercritical carbon dioxide via molecular structure and also to investigate the factors
that influence the solubility and extraction of analytes in a supercritical fluid
extraction (SFE) when using carbon dioxide as the solvent.
The polarity of an analyte was selected as the key parameter to developing a means of
estimating steroid solubility in supercritical carbon dioxide. Polarity can be estimated
by the hydrophobicity term, log P (based on partition coefficients), and also of the
solubility parameter, 0,. The use of partition coefficient in conjunction with a
calculated solubility parameter was demonstrated as a reasonable means of estimating
steroid solubility in supercritical carbon dioxide. Experimental determination of the
solubility of several steroid compounds with a range in polarities in supercritical
carbon dioxide was carried out in order to correlate solute polarity to the solute
solubility. A chromatographic method was also investigated based on capacity factor
measurements for the prediction of steroid solubility in supercritical carbon dioxide.
The application of supercritical fluid extraction (SFE) \\